Frequently Asked Questions

Olfactive Biosolutions repurposes food molecules, utilizing ectopic receptors to elicit physiological benefits comparable to drugs.

This innovative approach explores the potential of olfactory, taste and ectopic receptors in harnessing therapeutic effects of common food, beverage and fragrance ingredients.

Pivit is a line of precision-therapeutic products that comprise proprietary formulations of food, beverage or fragrance molecules.  

These formulations are designed to activate ectopic receptors in the gut and elsewhere to provide beneficial physiological effects such as GLP-1 and GIP secretion for potential weight loss and blood sugar reduction.  Other Pivit formulations correlate ingredients to receptor activity that releases neurotransmitters such as serotonin and thus potentially help to relieve anxiety or depression.

Olfactive Biosolutions sells these formulations to food and beverage and consumer packaged goods companies for inclusion in their products, such as snacks, bars, coffee and other products, and direct to consumer as supplements.

"Lack of hunger"

"Feeling a lack of interest in food"

 "Indifference to food, no cravings (for sweets or alcohol or bread)"

 "Lost 3.3 lbs in 7 days"

"Subverts cravings"

 "Produces a general mellowness"

 "Needed to force myself to drink protein shakes after taking Pivit"

“Lost 15 lbs in 14 days”

“Lost 11 lbs in less than two weeks”

“Back to my high-school weight”

“Blood sugar level went down to average of around 98 mg/dL from average range of 110-123 mg/dL

“Completely turned off food noise”

“Pivit supports my fasting and helps me burn calories all the way through my fasting period”

"Uninterested in food"

"When eating, leaves sensation of being full/overfull"

"After three days lack of interest in sweets or snacking"

“Eliminated my after-dinner snacking”

Olfactive Biosolutions sells its Pivit line of proprietary health and wellness formulations to large food and beverage and consumer packaged goods companies for new product development and inclusion in existing products.  We also sell Pivit direct to consumer as supplements. We also license our technology to selected third parties.

We use natural food molecules found on the FDA-approved GRAS (Generally Recognized as Safe) list.

No, Pivit is not an FDA-approved drug. 

While Olfactive Biosolutions is developing products with therapeutic potential, they are not FDA-approved as drugs, but rather as ingredients for food and beverage products.

Examples of Products:

• Pivit Weight Loss: A line of natural food ingredients and additives targeting weight loss and blood sugar reduction.
• Pivit Blood Pressure: A formulation to reduce blood pressure, available as a supplement.

Olfactive Biosolutions uses proprietary formulations of food molecules to activate ectopic receptors in the body, to replace pharmaceuticals and treat myriad chronic diseases.

This approach promises the ability to bring health and wellness to large parts of the globe.  Food molecules are cheap and plentiful. We have been eating them for millennia.  Unlike pharmaceuticals, they have few side effects and can be consumed on a long-term basis.

Olfactory receptors (ORs) and taste receptors (TRs) occur in the nose and tongue and allow us to smell and taste the world, sensing up to one trillion different tastes and smells.  These same receptors occur throughout the body, where they are generally referred to as ectopic receptors.  These ectopic receptors participate in diverse biological processes, including the regulation of glucose and lipid metabolism.

Ectopic ORs and TRs can regulate a variety of metabolic events including insulin secretion, glucagon secretion, fatty acid oxidation, lipogenesis, and thermogenesis. Understanding the physiological function and deciphering the olfactory recognition code by suitable ligands make ectopic ORs and TRs potential targets for treating many different diseases.

Olfactive Biosolutions’ Pivit line of formulations are sold DTC as supplements.  They are also incorporated into food and beverage products on a royalties basis.  The company also licenses its patents and technology to supplements companies and compounding pharmacies.

Olfactive Biosolutions has developed world-leading receptor technology and expertise in both olfactory and taste receptors in the nose and tongue, and ectopic receptors in the gut, lungs, skin, heart, blood and elsewhere. 

Our TruePath platform for working with these receptors and the ligands that interact with them comprises our proprietary cell lines, DNA sequences, genes encoding required accessory and assay signaling proteins, proprietary protein expression techniques, cellular assays, liquid handling robots and our proprietary software, machine learning algorithms and receptor-trained AI. 

The platform allows us to perform rapid high-throughput screening of food, beverage and fragrance molecules against a host of receptors in different parts of the body to determine which are promising for affecting various physiological pathways.

Pivit® GLP-1 Activator is an oral, food-molecule formulation designed to stimulate the body’s own incretin response—primarily by activating chemosensory (ectopic olfactory/taste) GPCRs in the gut. That receptor signaling prompts enteroendocrine cells to increase GLP-1 (and related satiety hormones like PYY/GIP), which can reduce appetite, slow gastric emptying, and improve post-meal glucose control.

We have extensive proprietary data from thousands of experiments about which food, beverage, and fragrance ligands interact with various human receptors (olfactory, taste, free fatty acid, TRP, trace-amine-associated receptors etc) and the extent of the activity they cause. 

We have extensive proprietary information about how the ligands cause conformational changes to the affected receptors.

At Olfactive Biosolutions, AI isn't a buzzword — it's the engine behind our discovery platform.

Here's how we're using it:

🔬 AI Structure Prediction — We use Boltz (an open-source AlphaFold3-equivalent) to build high-quality homology models of olfactory receptors, giving us a detailed map of where molecules can bind.

⚗️ AI-Trained Docking — Our dual-scoring pipeline (smina + gnina + Autodock Vina) screens 4,500+ food molecules against each receptor, surfacing the strongest candidates while filtering out false positives.

🔄 A Self-Improving Data Moat — Every wet-lab validation generates real EC50/IC50 binding data that retrains our models. The AI gets smarter with every receptor campaign.

The result? We've docked 7 receptors to date — including OR51E1, OR51E2, and OR2W1 — identified chemically coherent, FEMA/GRAS-validated hits, and filed a patent on AI-predicted food ligand docking.

We didn't build AI on top of science. We built the science first — 402 human olfactory receptors cloned over 8+ years — and used AI to unlock what was always there.

That's the TruePath® difference.